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Summary: Mounjaro (tirzepatide) is not officially linked to period spotting, but menstrual changes may occur indirectly through rapid weight loss and hormonal shifts affecting the hypothalamic-pituitary-ovarian axis

On examination, there is no visible perianal abnormality

These timelines represent a general pattern, not a guarantee

Allow a complete washout period of four to six weeks before considering resumption at dramatically reduced levels

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Rotate sites systematically (abdomen, lateral thigh, upper arm, buttocks) to avoid lipohypertrophy [8]