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Conclusions Mechanistic and preliminary clinical evidence have consistently pointed toward beneficial effects of GLP-1 analogues and GLP-1R agonists on cardiovascular diseases in T2D patients

Carefully manage the use of diuretics and RAAS blockers (e.g., ACE inhibitors, ARBs)

Effect of viscous fiber supplementation on obesity indicators in individuals consuming calorie-restricted diets: a systematic review and meta-analysis of randomized controlled trials

Safety Information & Warnings Comprehensive safety and efficacy data will become available upon completion of the phase 3 trials

From this it appeared to Holst that something had changed in their gut that altered its metabolism

Aging models Given the close association between diabetes, aging, and neurodegeneration, GLP-1RAs have been tested in in vivo aging models