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N Engl J Med 355:24272443 Patane G, Piro S, Rabuazzo AM, Anello M, Vigneri R, Purrello F (2000) Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells

In contrast, gastrointestinal side effects were reported in 10 of the 11 studies and were consistently more common in the intervention groups

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