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Serious side effects (rare but important): Gallbladder problems (risk increases with rapid weight loss) Pancreatitis (inflammation of pancreas) Thyroid C-cell tumors (seen in animal studies, not confirmed in humans) Severe gastroparesis (stomach paralysis in extreme cases) Hypoglycemia if combined with other diabetes drugs Who shouldn't use these drugs: Personal or family history of medullary thyroid cancer Multiple endocrine neoplasia syndrome type 2 History of pancreatitis Severe gastroparesis or digestive issues Pregnant or trying to conceive Dosing and injection frequency Both drugs are once-weekly injections

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Celebrities and influencers such as Oprah Winfrey, Elon Musk and Rachael Knight Guellete are confirmed to be using GLP-1s and will often be seen promoting these products

The organization recommended label changes to classify NAION as a very rare side effect for EU-marketed drugs

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