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Compounded GLP-1s have not been evaluated by the FDA, but side effects are expected to be similar to other GLP-1-based medications reviewed by the FDA, which have the following side effects: nausea, diarrhea, vomiting, constipation, abdominal (stomach) pain, headache, fatigue, dyspepsia (indigestion), dizziness, abdominal distension, eructation (belching), hypoglycemia (low blood sugar), flatulence (gas buildup), gastroenteritis (an intestinal infection), and gastroesophageal reflux disease (a type of digestive disorder)

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Areas with predominantly White residents, high median household income and low social vulnerability had the second highest off-label prescription rate (42.2%)

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By simultaneously activating both GIP and GLP 1 receptors, tirzepatide engages complementary and potentially synergistic mechanisms involved in energy balance and glucose regulation