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Manipulating ferritin levels through ferritinophagy can influence the iron abundance and the susceptibility to ferroptosis (50, 51)

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[DOI] [PubMed] [Google Scholar] 26.M, Ingersoll RT, Lykkesfeldt J, et al

However, other PDZ-binding proteins are known to also regulate CFTR localization and function, including NHERF2 55,84 , CAL (CFTR-associated ligand) 85 , and CAP70 (CFTR associated protein) 86 Furthermore, other non-PDZ-dependent mechanisms may contribute, since the physiologic dimers of CFTR are assembled independently of either NHERF1 or NHERF2, thus leaving PDZ-domains available for other interactions 55