Distinguishing direct pharmacological anti-inflammatory actions from secondary metabolic improvements requires further mechanistic studies and randomized controlled trials specifically designed to assess inflammatory outcomes as primary endpoints
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Rodrguez-Rodrguez et al., 2014) such as myeloperoxidase, a heme enzyme secreted by human artery wall macrophages which oxidizes apolipoprotein A-I (apoA-I), the major HDL protein, diminishing apoA-I ability to promote cellular cholesterol efflux
As the dose increased to 16 mg, inflammatory marker CRP continued to show a significant improvement amongst other inflammatory bio-marker improvements
Interestingly, studies examining placental passage of exenatide and liraglutide in human cases suggest minimal to no fetal exposure shortly after administration, indicating that maternal metabolic effects, rather than direct fetal exposure, may contribute to adverse outcomes