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Other hormonal treatment may be tried if these are not effective

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5-Methyl THF serves as a methyl donor in the vitamin B 12 -dependent reactions catalyzed by methionine synthase, which remethylates homocysteine to methionine, regenerating THF

Int J Obes (Lond) (2006) 30:172936.10.1038/sj.ijo.0803344 11 LockieSHHeppnerKMChaudharyNChabenneJRMorganDAVeyrat-DurebexCet alDirect control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling