Closely monitor the efficacy of these drugs, especially when using medicines with a narrow therapeutic index (such as warfarin)
Even a little bit helps more than not doing it at all
A three-month compression in the exclusivity runway, from month 36 to month 33 post-announcement, can represent hundreds of millions of dollars in revenue impact for a large-revenue asset
And as more people are able to access these drugs, it will be important to understand who benefits most from using them, how long they should be used for and what extra medical support would be needed to ensure people can keep the weight off
RNA splicing is a primary link between genetic variation and disease
Losing 1020 pounds may take a few months, while 4070+ pounds typically requires long-term, consistent treatment