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These are mechanism-based and native-drug considerations

513,514 These signaling pathways suggest that GLP-1 and its receptor agonists may influence the progression of NASH through multiple mechanisms, providing several potential therapeutic targets including: FOXO1, a transcription factor that plays a critical role in regulating glucose and lipid metabolism

Its commonly described as a selective agonist at the ghrelin or growth hormone secretagogue receptor, which means it acts more like a precise switch than a broad hormonal flood

This combination does not exist

Secondly, the existence of residual confounding factors cannot be completely excluded despite the adjustment of potential confounding factors

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