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Key takeaways Most people start with a low dose of GLP-1s for weight loss

However, for reasons that are incompletely understood, in preclinical and clinical studies, adding either a GIPR agonist or GIPR antagonist to GLP-1R agonism causes additional weight loss 1

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Most of the time, the issue is either incorrect dosing, a protocol not matched to their specific labs, or a compound thats not the right fit for their goals

[DOI] [PMC free article] [PubMed] [Google Scholar] 205.Yoshino T., Shiina H., Urakami S., Kikuno N., Yoneda T., Shigeno K., Igawa M