An eGFR just below 60 typically indicates the presence of early-stage CKD and is also associated with a significantly increased risk of cardiovascular and any-cause mortality, kidney failure, acute kidney injury, or the progression of CKD
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The antinociceptive effect was completely blocked by minocycline (a microglial inhibitor), -endorphin antiserum, or naloxone (an opioid receptor antagonist) [24]
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