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For increased patient safety in APAP consumption, the FDA has worked to mitigate APAP hepatotoxicity by legislating regulations to limit prescription combination drug products to have no more than 325 mg of APAP per dosage unit and have urged healthcare providers to cease prescribing combination drug products with more than 325 mg of APAP per tablet

Lotiglipron was discontinued in 2023 owing to unfavourable pharmacokinetic drug-drug interaction data from two Phase I studies and to elevated transaminases indicative of liver dysfunction in a subset of patients 24

This relies on choosing a platform that enables you to quickly develop and validate immunoassays that also involve short assay run times to boost productivity