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The 22.7% result exceeded what simple addition would predict (11.8 + 16.1 = 27.9, minus baseline placebo effect)

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Clinical activity of AMG 337, an oral MET kinase inhibitor, in adult patients (pts) with MET-amplified gastroesophageal junction (GEJ), gastric (G), or esophageal (E) cancer [abstract]

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Some investigators have proposed that GLP-1RAs improve myocardial insulin sensitivity, enhance glucose oxidation rates, reduce fatty acid oxidation, and thereby optimize myocardial energy metabolism, ultimately improving cardiac function.106 In a randomized controlled trial (RCT) conducted by Mikhail et al,106 semaglutide efficacy was evaluated in 616 patients with obesity-related heart failure and T2DM