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As early as 1990, Bowers and colleagues showed that the joint administration of a GH-releasing peptide and GHRH produces a GH peak far above either substance alone, and that this occurs via separate mechanisms (Bowers et al., 1990)

All animal experiments performed in this study were approved by the relevant ethics committees, and all experimental procedures comply with local laws and ethical standards

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The relationships of the metabolic pathways are illustrated in Fig