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Another type of post-translational modification is methylation by arginine methyltransferases (PRMTs), in which arginine can be methylated to either monomethylated arginine or dimethylated arginine

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In fibrotic liver tissues, the inactivation of the Hippo pathway results in the aberrant activation of YAP/TAZ and their translocation into the nucleus, thereby initiating a cascade of gene programs that promote the activation of hepatic stellate cells and drive the progression of liver fibrosis [46]