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Nature and extent of penicillin side-reactions, with particular ref erence to fatalities from anaphylactic shock

Long-term safety data in extended rodent studies (90+ days) would be essential before translating this to human protocols

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Overall signal: Reviews summarize broad preclinical benefits but emphasize minimal human data and the need for trials before clinical adoption

Most compounding pharmacies assign a beyond-use date of 28 to 90 days from preparation when stored at 2 to 8 degrees Celsius