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To maintain the dynamic equilibrium of the mitochondrial proteome, cells have evolved a sophisticated mitochondrial protein quality control (PQC) system that counters multiple stressors including aberrant polypeptide import, protein misfolding, oxidative damage, and metabolic byproduct accumulation [5,6,7]

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An imbalance between free radical production and the bodys antioxidant defenses leads to oxidative stress, which is implicated in the pathogenesis of numerous diseases (Table 2) [8]

The identified proteins offer promising biomarkers and therapeutic targets, paving the way for improved diagnosis, treatment, and patient outcomes in gallbladder disease