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Characterising this bidirectional relationship is an open research question, and the work is early-stage

SAM is a methyl group donor for numerous methylation reactions in the brain, including those involved in the metabolism of neurotransmitters whose deficiency has been related to depression (102)

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Copper toxicity

It stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat accumulation)

In clinical studies, it has been shown to have beneficial effects on skin aging, muscular homeostasis, diabetes, Alzheimer disease, cardiovascular disease, and osteoporosis