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doi: 10.1056/NEJMoa2032183 45 FilippatosTDPanagiotopoulouTVElisafMS

According to the CDC, those with a normal BMI are recommended to gain 25 to 35 pounds (while those with overweight or obesity are recommended to gain slightly less)

Patients with genetic predispositions toward strong GLP-1 pathway activation may achieve target outcomes at lower doses, while those with less responsive pathways might benefit from extended time at higher therapeutic levels

Wellness is a journey, not a sprint

Drug Effect Weight loss itself can rob bone density through four pathways: Mechanical unloading less body weight and fewer impact forces Hormonal shifts leptin and estrogen fall as fat shrinks Nutrient shortfalls calorie cuts often mean less calcium and protein Muscle loss weaker muscles increase fall risk and provide less bone-stimulating tension Banner Health notes that even dropping 10 lb in three months can measurably lower BMD in older adults

2023, doi: 10.1016/S0140-6736(23)01053-X