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A report to the Committee on Safety of Drugs

SLC6A14, a Na+/Cl-coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling

GBTs lead to substantially reduced caloric intake by increasing satiety, suppressing appetite, decreasing hunger, reducing gastrointestinal (GI) and biliary motility, and slowing gastric emptying [14,15]

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It can affect the liver microenvironment through GLP-1R in the immune system, adipose tissue, intestines, and the liver