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PlexusDx emphasizes that semaglutide may indirectly increase cardiovascular strain in certain scenariosrapid weight loss can temporarily elevate heart rate, and dehydration from gastrointestinal side effects may reduce blood volume

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For some patients, nausea triggers additional appetite loss, amplifying weight loss, but for others it reduces food tolerance temporarily

Behavioral Support: Long-term success with GLP-1 medication often involves ongoing lifestyle modifications, including healthy eating habits and regular physical activity

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Reduced overall food intake, less fluid, and slower gut motility (how quickly the intestines move) can all stack the deck