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The most effective balance of GLP-1, GIP, and glucagon activity may differ by patient phenotype, diabetes status, degree of obesity, hepatic steatosis, baseline insulin resistance, and tolerability profile

The Phase 2 trial published in the New England Journal of Medicine showed up to 24.2% weight loss at 48 weeks

The specific arrangement enables MOTS-c to penetrate cells and, under certain conditions, translocate to the nucleus where it can influence gene expression directly

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Do not take tirzepatide if you are pregnant, planning to become pregnant, or breastfeeding