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Their amphiphilic nature, characterized by a hydrophobic core and a hydrophilic surface, enables them to carry a wide range of therapeutic agents, making them effective vaccine delivery systems [87]

According to the defined criteria for core targets selection, the top 10 core genes for osteogenic/osteoclastic process regulated by riboflavin were HIF1A, HDAC4, HDAC3, HDAC2, BCL2, TP53, MYC, NFKB1, PPARG and PPARGC1A (Figs