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That pattern is the rationale for the compound's relatively mild side effect profile in controlled trials

Vet Med Sci 9(6):27962799 Nuguru SP, Rachakonda S, Sripathi S, Khan MI, Patel N, Meda RT (2022) "Hypothyroidism and depression: a narrative review." Cureus 14(8)

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The binding between GLP1 and GLP1R on various cells can activate adenylyl cyclase and increase cAMP levels, which further stimulates protein kinase A and cAMP-regulated guanine nucleotide exchange factor 2 pathways and insulin secretion [90,91]

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