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In 2022, tirzepatide was launched, becoming the worlds first new-generation drug that acts on both GLP-1R/GIPR targets

Functional effects in the pancreas include the glucose-dependent release of insulin, as well as an up-regulation of the biosynthesis of insulin, glucokinase, and glucose transporters

Through attenuation of chronic hypothalamicpituitaryadrenal (HPA) axis overactivation, adaptogens such as Withania somnifera can normalize thyrotropin-releasing hormone (TRH) and thyroid-stimulating hormone (TSH) signaling, thereby improving peripheral thyroid hormone bioavailability (186)