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High body mass index (BMI) has been shown to increase joint inflammation, exacerbating pain

A medication review should be conducted to identify drugs that might contribute to cramping (statins, diuretics)

Novo Nordisk has been conducting late-stage clinical trials on higher doses of oral semaglutide, specifically 25 mg and 50 mg tablets, aimed at weight loss rather than just diabetes

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In individuals with T2DM, chronic hyperglycemia is known to downregulate GIPR expression and impair GIP-stimulated insulinotropic activity, thereby limiting the efficacy of GIP monotherapy [21]

For individuals of Asian, Black African, or African-Caribbean family origin, lower BMI thresholds apply (typically 2.5 kg/m lower) due to increased metabolic risk at lower body weights