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El-Lakkany et al., 2016 [42] showed that beyond improving serum lipid levels, NAC taken with a diet at 150 mg/kg for 8 weeks could improve the biochemical and histological parameters related to hepatic steatosis such as lobular inflammation and fibrosis, while enhancing liver function enzymes such as serum alanine amino transferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma glutamyl transferase in HFD-induced rats

Unexpected jaundice, dark urine, or persistent vomiting should be reviewed promptly

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Journal of Holistic Integrative Pharmacy 4(4):299309 Ahmed WA, Qatea FK, Qasim BJ, Nashtar SB, Al-Radeef MY (2023) Effects of silymarin against hepatic and renal toxicity induced by methotrexate in rats

15 (2018): 39573965, 10.1021/acs.jafc.8b00937

All of the NSAIDs induced both lower esophageal and pyloric sphincters pressure fall and, thereby, the induced sphincter failure may be a common phenomenon for NSAIDs, with some particularities for the NSAIDs used, namely, diclofenac, ibuprofen, aspirin, paracetamol and celecoxib