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But risks are rarely isolated within a single dataset

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Footnotes: 1) Hayashi N, Iida T, Yamada T, Okuma K, Takehara I, Yamamoto T, Yamada K, Tokuda M. Study on the postprandial blood glucose suppression effect of D-psicose in borderline diabetes and the safety of long-term ingestion by normal human subjects. Biosci Biotechnol Biochem. 2010;74(3):510-9. doi: 10.1271/bbb.90707. Epub 2010 Mar 7. PMID: 20208358

When enough anomalies accumulate, they create what Kuhn calls a crisis, a loss of confidence in the status quo because the existing paradigms no longer apply