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de Mol J, Kuiper J, Tsiantoulas D, Foks AC

It has the same chemical structure as GLP-1 peptide Cagrilintide, with amino acid changes and fatty acid acylation, but it works on a different set of receptors

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Monotherapy data suggests cagrilintide is effective at 2.4 mg weekly and retatrutide at 8-12 mg weekly, but these doses cannot simply be combined without understanding potential interactions

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However, GRP78 can be transferred to mitochondria and lysosomes, especially via ER-adjacent portions of their membranes, and can be transported to the cytosol to be secreted from cells