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Among these, SIRT1, predominantly distributed in the nucleus and cytoplasm, is considered a key metabolic regulator in various tissues

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doi: 10.1002/wsbm.1518 7 ArtisD

) can induce early cell senescence by activating p16 ink4a and p21 Cip1 pathways, which is initially manifested as temporary cell cycle arrest to promote DNA repair

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