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Treatment consists of taking in vitamin B-12 by mouth or by injection, initially in high daily oral doses.If your anemia is due to a chronic disease, treatment of the underlying disease will often improve the anemia

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In addition to fatigue, a deficiency of B12 can lead to other symptoms like pale skin, headaches, depression, gastrointestinal problems, difficulty concentrating, decreased mental function, mouth and tongue pain or inflammation, and paresthesia in your hands and feet