Slightly positive or near-neutral zeta potentials (approximately 10 to +10 mV) are generally preferred for systemic administration because highly cationic particles can strongly bind to the negatively charged endothelial glycocalyx and plasma proteins, causing aggregation, complement activation, and membrane damage (120)
For visible results in hyperpigmentation and radiance, a glutathione supplement like Glutone 1000 is usually the more effective choice
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