This design choice introduces potential bias, particularly for subjective outcomes, but it reflects the practical reality that these treatments have different injection devices and titration schedules that would make blinding extremely difficult
In addition, integration with existing cancer therapies, including surgery, radiotherapy, and targeted therapies remain unstudied
In contrast, betaine acts as a methyl donor in one-carbon metabolism, maintains cellular S-adenosylmethionine levels, and protects the cells from the harmful effects of increased plasma homocysteine
The difference between a smooth injection and a painful one comes down to controllable details like allowing alcohol to dry completely, injecting slowly over several seconds, and rotating between abdomen, thigh, and upper arm sites
The company also offered other sizes in the past, but those have been discontinued
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