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If you are taking glutathione and feel a "detox" sensation (like mild fatigue or a headache), ensure you are drinking enough water to help your body process the toxins being mobilized

Muller TD, Finan B, Bloom SR, et al

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Because it modulates cellular NAD+ availability and mitochondrial function, some protocols administer it in the morning to align peak NNMT inhibition with waking metabolic activity