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Key Benefits Mechanism of Action Retatrutide is a triple agonist of GLP-1, GIP, and glucagon receptors

Patients with higher initial BMI may experience greater absolute weight loss but similar percentage reductions compared to those with lower starting weights

However, new research suggests they may also carry potential risks related to bone health and gout, particularly when rapid weight loss occurs

Tirzepatide carries a boxed MTC warning and a characterised pancreatitis / gallbladder / hypersensitivity profile 28 29

For detailed comparison, see the complete medication comparison

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