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The genes downregulated with semaglutide were significantly enriched in SMAD3 transcription factor motifs, an effector of canonical TGF signalling, as well as ZNF322 and NFY motifs, transcription factors responsive to noncanonical TGF signalling, consistent with the semaglutide-induced decrease in TGF signalling also observed in cardiac myocytes and fibroblasts

[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Scrocchi LA, et al

These therapies traditionally were used to treat diabetes

Wang W, Wang CY, Wang SI, Wei JC

The target

This is one reason people sometimes stop losing weight without changing anything, degraded medication delivering less drug than expected