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Clinical trials are now underway in patients with obesity using these mAbs in combination with GLP1-receptor agonists to explore this important possibility (www.clinicaltrials.gov, NCT06299098)

GLP-1 receptor agonists offer a promising solution for T2DM management, aiding glycemic control while addressing the weight management challenges associated with diabetes

Sjholm, K

These medications improve insulin secretion, slow gastric emptying, and activate metabolic pathways that benefit patients regardless of starting body weight

Sleep Medicine, 11(7), 692-700

J Endocrinol 221:T3141 Holz GG, Kang G, Harbeck M, Roe MW, Chepurny OG (2006) Cell physiology of cAMP sensor Epac