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For example, in amyotrophic lateral sclerosis (ALS), HSP70s may modulate mutant proteins such as SOD1, FUS, C9orf72, and TARDBP by preventing their solidification or facilitating their disaggregation and/or clearance via autophagy
Natural compounds offer a promising alternative, given their ability to modulate multiple pathways simultaneously
This study was partly supported by ACT-X (for K.K., JPMJAX1915 from Japan Science and Technology Agency), KAKENHI (18K14281 for K.K
any particles or cloudiness mean its gone bad
Nature 504, 291295
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