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These patients often have fluctuating hormone levels rather than the flat postmenopausal profile, which makes fixed-dose commercial products a less precise fit

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For example, semaglutide for type 2 diabetes (Ozempic) typically begins at 0.25 mg weekly, gradually increasing to maintenance doses of 0.5 mg, 1 mg, or 2 mg

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however, when rigorously designed using proven analytic approaches to emulate reference trials, real-world evidence of several glucose-lowering drug classes have demonstrated strong concordance with trial estimates 20,22,32

10.1097/MD.0000000000011337 Medicine 220 YuH.SunT.AnJ.WenL.LiuF.BuZ.et al (2020)