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doi: 10.1155/2016/2986796 18 CuiY.HanY.YangX.SunY.ZhaoY

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Activated M1 (or pro-inflammatory) microglia are part of an inflammatory cascade that includes upregulation of pro-inflammatory genes, release of pro-inflammatory cytokines, and generation of ROS, which may, under prolonged conditions, contribute to the neuroinflammation observed in AD brain [97]

This results in the formation of erythrose-4-phosphate and fructose-6-phosphate

An unrelated monoclonal antibody neutralizes human immunodeficiency virus type 1 by binding to an artificial epitope engineered in a functionally neutral region of the viral envelope glycoproteins

It survives exposure to stomach acid for over 24 hours, remains active across a wide pH range, and resists degradation by digestive enzymes