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If you inject semaglutide, inject 30 minutes before your largest meal of the day, ideally lunch rather than dinner

Topiramate primarily influences appetite through neurological pathways, while Semaglutide (Ozempic) modulates hunger and satiety via hormonal GLP-1 pathways and slows gastric emptying

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Together, these hormones strengthen blood sugar control and amplify fullness signals in the brain (Mozaffarian, 2025)