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Researchers have proposed that inhibiting NNMT may influence downstream metabolic pathways by altering nicotinamide utilisation and methyl donor availability

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Metabolic pathway requiring 5-deoxyadenosylcobalamin The figure illustrates the metabolic pathway for the vitamin B 12 -dependent enzyme L-methylmalonyl-CoA mutase, which converts L-methylmalonyl-CoA into succinyl-CoA for entry into the citric acid cycle