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First, dose-escalation with 4-week intervals at each step is the validated approach jumping directly to target dose is not how the clinical data was generated

Over an entire body's lean mass, this adds up to hundreds of calories of daily metabolic protection (Westerterp-Plantenga et al., Annu Rev Nutr 2009)

J Neurol Neurosurg Psychiatry 89(10):10881100 Mollan SP et al (2019) The expanding burden of idiopathic intracranial hypertension

Over time, many people notice a significant reduction in appetite, which can help with portion control and mindful eating

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