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Biochem Pharmacol, 2017
Half-life and clearance timing Peptide half-life determines initial clearance rates
Frequency varies based on vitamin B12 deficiency severity and underlying risk factors
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Toxicology assessments in rats found no organ toxicity at doses up to 10 mg/kg (approximately 1000x the effective dose), no mutagenicity in Ames testing, and no teratogenic effects
What the research shows: A phase 2 randomized, double-blind, placebo-controlled trial published in the New England Journal of Medicine (Jastreboff et al., 2023) enrolled 338 adults with obesity
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