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This is why Phase 3 TRIUMPH protocols allow dose reduction rather than discontinuation when a participant approaches a low BMI

Mentias A, Aminian A, Youssef D, Pandey A, Menon V, Cho L, et al

Prolonged elevation of blood glucose, as well as related adverse metabolic features such as dyslipidemia and chronic inflammation, lead ultimately to a range of debilitating health issues such as, cardiovascular disease, peripheral neuropathy, diabetic ketoacidosis, diabetic retinopathy, and diabetic nephropathy

This unique trifecta of receptor affinity makes Retatrutide a significant focus in biochemical research involving multi-pathway endocrine signaling