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That is an issue because a dehydrated athlete will have more concentrated urine relative to a well-hydrated athlete, and so the concentration of any substances (prohibited or not) appearing in their urine will be higher, thus increasing the probability of an anti-doping rule violation being pursued against them simply because of their hydration status

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No reconstitution is needed for topical formulations

This fragment retains the key properties of the parent molecule while offering better experimental manageability and a reduced molecular mass