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The compound that yielded the highest in vitro efficacy and potency was 2,5Pen-enkephalin (DPDPE) (Figure 5)
Neurotoxicology 29, 397405
Subject demographic and baseline characteristics are shown in Table 1 and were consistent across the five treatment arms
The vast majority of evidence comes from MCT or hypoxia animal models, whose pathological characteristics differ from human PH, lacking in-depth verification in models that are more similar to human disease states
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