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The angiogenic switch can be triggered either by additional genetic alterations of tumor cells, leading to increased proliferation and hypoxia or expression of pro-angiogenic factors, or by tumor-associated inflammation and recruitment of immune cells

Increased Energy and Mobility : As weight decreases, energy and physical mobility typically improve, encouraging a more active lifestyle

Symptoms must be present for at least six months, occur frequently, and impair aspects of function in academic, social, or occupational activities