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IGF-1 LR3 is modified at two positions (N-terminal 13-amino-acid extension and Arg3 substitution) to substantially reduce IGFBP-3 binding, extending preclinical activity duration well beyond the roughly 10 to 12 minutes seen with unbound native IGF-1

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AQP4 on astrocytic end-feet relocates towards the soma, causing astrocyte swelling, capillary compression, and decreased CBF [95,96,97]

An axial position above or below the square plane can be occupied by a more loosely bound water molecule, giving a square-pyramidal geometry in some conditions

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For the maintenance treatment of pernicious anemia, the usual dose is 100mcg SC/IM, given once every month